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Their More moderen do the job even more uncovered that the atypical GTPase domain of Fbx4 could serve as a substrate-binding motif with the SCF E3 ligase complex and bind to a globular area of TRF1 for its ubiquitination and degradation. These results supply clues on the underlying mechanism for managing TRF1, whose expression is tightly controlled

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Telomere metabolism and function are advanced, and it might be complicated to obtain an entire photo of the correlation. It seems that all These scientific studies give just a general standpoint around the postulated Affiliation, but considering The present point out of data on telomere biology, it might be really constructive.The study discovered

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